Anxiety and Depression: How They Connect

| T. Franklin Murphy

A red-haired woman rests her cheek on her hand beside a window, her gaze lowered and her reflection faintly visible.

A difficult change can leave us looking in two directions at once. We worry about what might happen next while grieving what has already changed. After losing a job, for example, a person may fear the next unpaid bill and feel a deep sadness about the familiar work, daily company, and sense of usefulness that disappeared. Concern and sorrow can occupy the same afternoon.

Understanding their connection begins with respecting both sides of this distinction. Painful feelings can help us respond to a difficult life. They can also become persistent, overwhelming, and disabling. We need room to acknowledge ordinary distress and to recognize when someone needs more care than reassurance can provide.

Anxiety and Depression: Similarities and Differences

Both can involve distress, unsettled sleep, trouble concentrating, irritability, and changes in activity. Those experiences alone do not neatly identify which condition is present. A person may feel exhausted by worry, anxious about their low mood, or troubled by both at once (National Institute of Mental Health, 2024a; National Institute of Mental Health, 2024b).

Overlapping symptoms do not necessarily mean that both disorders are present. When both are diagnosed, clinicians call this comorbidity. Research examines this co-occurrence as well as the overlap between symptoms (Jacobson & Newman, 2017).

Anxiety often brings possible danger to the foreground: What if something goes wrong, and will I be able to cope? Depression can make hope and worthwhile activity harder to reach. These are common patterns, rather than a rule that anxiety concerns only the future and depression only the past. Both conditions can shape what we notice and how we interpret events. For example, an uncertain situation may seem more threatening or discouraging than it otherwise would, although these patterns vary across people and diagnoses (Grupe & Nitschke, 2013; Pizzagalli, 2014; Lavigne et al., 2024).

Depression can also change how we experience things we usually enjoy. Anhedonia means a loss of interest or pleasure. Related difficulties may appear before an activity begins: a person might remember enjoying a walk with a friend yet feel little desire to go. Enjoying the moment, looking forward to it, and finding the energy to begin are related experiences, but they are not identical. Pizzagalli’s review explains why these different difficulties deserve attention when we try to understand depression (Pizzagalli, 2014).

Concern and Sadness in an Ordinary Life

Concern draws attention to what may need protection. An approaching deadline prompts preparation; uncertainty about a medical symptom prompts an appointment. Grupe and Nitschke describe anxiety as an anticipatory response to uncertain threat. In manageable forms, that capacity helps us consider consequences and prepare for difficulties before they arrive (Grupe & Nitschke, 2013).

Randolph Nesse’s smoke detector principle helps explain why defensive systems can produce false alarms when missing a threat would be especially costly. The analogy does not establish that every anxious feeling is accurate or useful, or that excessive anxiety should go untreated (Nesse, 2001).

Sadness often accompanies the loss of something valued. Richard Lazarus places the meaning of loss at the center of his account. Recognizing that an old possibility has closed can be part of adjusting to new conditions, but sadness need not immediately produce a plan. Mourning and accepting support may belong to that adjustment (Lazarus, 1991).

Concern may help us prepare; sadness may first ask us to acknowledge what preparation cannot restore. Protecting ourselves can include a pause or accepting care. These are possible responses to emotion, not obligations to turn every painful experience into something productive (Lazarus, 1991).

When Emotional Distress Becomes a Clinical Concern

The boundary is not simply whether a feeling is unpleasant. Its persistence, severity, context, and effect on daily life matter. Anxiety disorders involve more than occasional worry and can substantially restrict ordinary activities. Major depression generally involves symptoms most of the day, nearly every day, for at least two weeks, including depressed mood or loss of interest or pleasure. That threshold is part of an assessment, not an instruction to postpone seeking help (National Institute of Mental Health, 2024a; National Institute of Mental Health, 2024b).

A painful event does not settle the question. Having an understandable reason for distress does not rule out a disorder, and being deeply sad does not automatically mean someone is clinically depressed. We should attend to what the person is experiencing, what they can manage, and what support is available rather than trying to decide whether they have earned the right to feel this way (National Institute of Mental Health, 2024b).

How Anxiety and Depression Can Become Connected

Shared Vulnerabilities and Stressful Circumstances

There is more than one way to understand the overlap. Anxiety and depression may reflect shared vulnerabilities, arise amid the same difficult circumstances, or interact over time. Carleton’s review brings together models in which difficulty tolerating uncertainty is one proposed connection. A person may become preoccupied with what could go wrong while also losing confidence that their actions can help (Carleton, 2016).

Temperament, earlier experience, and present pressures can influence responses to uncertainty. A difficult situation may involve both future threat and losses already sustained, making the person’s circumstances as important to understand as their symptoms (Carleton, 2016; Grupe & Nitschke, 2013).

The Connection Can Run Both Ways

Timing is another part of the connection. Jacobson and Newman brought together 66 longitudinal studies involving 88,336 people. Across the symptom findings, anxiety predicted later depression, and depression predicted later anxiety. Patterns varied across particular disorders. This supports looking in both directions rather than assuming that anxiety always comes first (Jacobson & Newman, 2017).

Prediction, however, does not establish a single causal chain. Shared circumstances and vulnerabilities can help account for later difficulties. The useful clinical implication is to ask about both kinds of symptoms and follow their course; one person’s experience cannot be read directly from an average research pattern (Jacobson & Newman, 2017).

Recognizing both matters for care. The earlier studies reviewed by Jacobson and Newman link co-occurring conditions with greater difficulties in functioning and illness course. Asking about both helps keep one pattern of distress from obscuring the other (Jacobson & Newman, 2017).

Worry and Rumination

Worry and rumination often look like attempts to understand and protect ourselves. Worry rehearses what could happen; rumination revisits distress, its causes, and its implications. Their subjects overlap, and neither belongs exclusively to one diagnosis. Watkins’s review shows that repetitive thought can support preparation and recovery, but can also sustain anxiety and depressed mood (Watkins, 2008).

Consider the difference between asking, “What can I do about tomorrow’s bill?” and repeatedly asking, “Why can I never manage my life?” The first question may lead to information or a practical step. The second can widen one difficulty into a judgment about the whole self. Watkins identifies thought content, context, and the difference between abstract evaluation and concrete processing as important influences on whether repetition helps or harms (Watkins, 2008).

A person may move between these styles: anticipating failure, remembering previous disappointments, then interpreting exhaustion as evidence that nothing will improve. We do not need to forbid thought to notice when it has stopped producing understanding. A useful change may be to name the specific problem, identify what remains uncertain, and ask what information or assistance would make the next decision possible (Watkins, 2008).

How Withdrawal Can Narrow Life

Avoiding a feared situation can bring immediate relief. If that relief repeatedly determines our choices, there may be fewer chances to discover that some situations are manageable. Declining contact or putting off a task can also remove opportunities for support, accomplishment, or enjoyment. Anxiety-related avoidance and depression-related difficulty approaching rewards can therefore intersect in everyday behavior (Hofmann & Hay, 2018; Pizzagalli, 2014).

Imagine someone who stops attending a weekly gathering because they expect to be judged. Staying home reduces anxiety that evening. Over time, the person has less contact with friends and fewer experiences that might challenge the expectation of rejection. If low mood also makes the gathering seem unrewarding, returning can become harder. This is one possible reinforcing pattern, not an explanation for everyone who experiences both conditions (Hofmann & Hay, 2018; Pizzagalli, 2014).

The function of withdrawal matters. Leaving danger, setting a boundary, or taking a needed break may protect a person. Hofmann and Hay caution against treating all avoidance as harmful. Bonanno and Burton’s account of regulatory flexibility likewise emphasizes the fit between a response and its circumstances, including whether we adjust when the response stops helping. A quiet life is not automatically an unhealthy life (Hofmann & Hay, 2018; Bonanno & Burton, 2013).

Circumstances also determine which choices exist. Someone dealing with unsafe work, unaffordable care, or unreliable housing may need practical assistance and changes in their environment. Advising that person to approach every source of fear would miss the problem. Judging a response means considering the actual demands and resources of the situation (Hofmann & Hay, 2018; Bonanno & Burton, 2013).

When We Feel Bad About Feeling Bad

Distress can acquire another layer when we believe we should not be feeling it. Across four studies, Bastian and colleagues linked perceived social expectations about negative emotions with negative self-evaluation and greater distress. Their experiments also found that messages about the acceptability or social costs of negative emotion affected immediate emotional responses (Bastian et al., 2012).

After losing a job, a person may grieve the loss and then judge that grief: I should be handling this better. Making room for the sadness can lessen the demand to perform cheerfulness while a real difficulty remains. There can still be room to seek treatment and change the circumstances. Accepting that an emotion is present does not require treating everything that produced it as acceptable (Bastian et al., 2012).

Responding to Anxiety and Depression

Understand the Particular Pattern

The most useful starting point is often a description: what feels threatening, what has become difficult to enjoy, what gets postponed, and what relief or cost follows? A clinician can help distinguish overlapping conditions and other contributors to symptoms. Both anxiety and depression deserve attention when they occur together (National Institute of Mental Health, 2024a; National Institute of Mental Health, 2024b).

Restore Engagement at a Manageable Pace

Behavioral activation is a structured treatment for depression that helps people reconnect with meaningful activity and examine patterns of avoidance. It does not require someone to feel enthusiastic before every small step. In practice, a step might concern necessary care, a manageable responsibility, or contact with someone trustworthy rather than an ambitious attempt to become happy (Uphoff et al., 2020).

A Cochrane review brought together 53 trials involving 5,495 adults. In the studies comparing behavioral activation with cognitive behavioral therapy, the researchers did not find a clear difference in how well the treatments worked over the short term. That does not prove the treatments are equally helpful for everyone. Weaknesses in the evidence and limited longer-term findings reduce confidence in the comparison. The review supports behavioral activation as an option for adult depression; it does not establish the same benefit for every anxiety disorder (Uphoff et al., 2020).

For anxiety, cognitive behavioral treatment often includes carefully planned exposure: approaching situations that are feared but sufficiently safe, with support to learn from the experience. This differs from pushing someone into actual danger or insisting that every protective behavior be abandoned. The purpose and context of the behavior remain central (Hofmann & Hay, 2018).

Professional Care and Practical Support

Professional care may include psychotherapy, medication, or both, according to the assessment and the person’s needs. Seek help when symptoms persist or interfere with daily life; support is appropriate before a crisis. Thoughts of suicide or an inability to stay safe call for urgent help through local emergency or crisis services (National Institute of Mental Health, 2024b).

Alongside care, practical support can make a proposed step possible. A friend might sit with someone while they arrange an appointment, help with transportation, or share a simple meal. These offers cannot guarantee recovery. They can communicate something valuable: you do not have to prove that you are feeling better before you deserve company.

A Few Words by Psychology Fanatic

The person sitting with an unpaid bill may need a plan, space to mourn, and someone willing to stay beside them. Anxiety and sadness can tell us that important parts of life are at stake. When those feelings become overwhelming, understanding their possible purpose should deepen our care for the person experiencing them. It should never become a reason to leave them suffering alone.

We may not be able to restore what was lost or make tomorrow certain. We can sometimes make the next hour more supported: a conversation, an appointment, a small piece of necessary care. There is dignity in those modest beginnings, including the days when accepting help is the most workable action available.

Associated Concepts

  • Rumination: Repetitive attention to distress and its implications can connect anxious anticipation with depressed mood.
  • Generalized Anxiety Disorder: Persistent, difficult-to-control worry is one form of anxiety; the broader connection with depression extends beyond this diagnosis.
  • Cognitive Behavioral Therapy: A family of treatments that addresses relationships among thoughts, emotions, and behavior.
  • Anhedonia: A loss of interest or pleasure that can accompany depression, making previously enjoyable activities feel less inviting or rewarding.
  • Uncertainty Avoidance: A tendency to avoid unpredictable situations. Difficulty tolerating uncertainty can connect anxious anticipation with discouragement and withdrawal.
  • Behavioral Activation: A structured treatment approach for depression that helps people reconnect with meaningful activities and examine patterns of avoidance.

Resources

Bastian, Brock; Kuppens, Peter; Hornsey, Matthew J.; Park, Joonha; Koval, Peter; Uchida, Yukiko (2012). Feeling Bad About Being Sad: The Role of Social Expectancies in Amplifying Negative Mood. Emotion, 12(1), 69–80. DOI: 10.1037/a0024755.
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Bonanno, George A.; Burton, Charles L. (2013). Regulatory Flexibility: An Individual Differences Perspective on Coping and Emotion Regulation. Perspectives on Psychological Science, 8(6), 591–612. DOI: 10.1177/1745691613504116.
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Carleton, R. Nicholas (2016). Into the Unknown: A Review and Synthesis of Contemporary Models Involving Uncertainty. Journal of Anxiety Disorders, 39, 30–43. DOI: 10.1016/j.janxdis.2016.02.007.
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Grupe, Dan W.; Nitschke, Jack B. (2013). Uncertainty and Anticipation in Anxiety: An Integrated Neurobiological and Psychological Perspective. Nature Reviews Neuroscience, 14(7), 488–501. DOI: 10.1038/nrn3524.
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Hofmann, Stefan G.; Hay, Aleena C. (2018). Rethinking Avoidance: Toward a Balanced Approach to Avoidance in Treating Anxiety Disorders. Journal of Anxiety Disorders, 55, 14–21. DOI: 10.1016/j.janxdis.2018.03.004.
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Jacobson, Nicholas C.; Newman, Michelle G. (2017). Anxiety and Depression as Bidirectional Risk Factors for One Another: A Meta-analysis of Longitudinal Studies. Psychological Bulletin, 143(11), 1155–1200. DOI: 10.1037/bul0000111.
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Lavigne, Katie M.; Deng, Jiaxuan; Raucher-Chéné, Delphine; Hotte-Meunier, Adèle; Voyer, Chloe; Sarraf, Lisa; Lepage, Martin; Sauvé, Geneviève (2024). Transdiagnostic Cognitive Biases in Psychiatric Disorders: A Systematic Review and Network Meta-analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 129, 110894. DOI: 10.1016/j.pnpbp.2023.110894.
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Lazarus, Richard S. (1991). Emotion and Adaptation. Oxford University Press. ISBN: 0195069943.
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National Institute of Mental Health (2024a). Anxiety Disorders. National Institutes of Health. Last reviewed December 2024. Accessed October 18, 2026. Website: NIMH Anxiety Disorders.
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National Institute of Mental Health (2024b). Depression. National Institutes of Health. Revised 2024; NIH Publication No. 24-MH-8079. Accessed October 18, 2026. Website: NIMH Depression.
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Nesse, Randolph M. (2001). The Smoke Detector Principle: Natural Selection and the Regulation of Defensive Responses. Annals of the New York Academy of Sciences, 935, 75–85. DOI: 10.1111/j.1749-6632.2001.tb03472.x.
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Pizzagalli, Diego A. (2014). Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model. Annual Review of Clinical Psychology, 10, 393–423. DOI: 10.1146/annurev-clinpsy-050212-185606.
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Uphoff, Eleonora; Ekers, David; Robertson, Lindsay; Dawson, Sarah; Sanger, Emily; South, Emily; Samaan, Zainab; Richards, David; Meader, Nicholas; Churchill, Rachel (2020). Behavioural Activation Therapy for Depression in Adults. Cochrane Database of Systematic Reviews, 7, CD013305. DOI: 10.1002/14651858.CD013305.pub2.
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Watkins, Edward R. (2008). Constructive and Unconstructive Repetitive Thought. Psychological Bulletin, 134(2), 163–206. DOI: 10.1037/0033-2909.134.2.163.
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Last Update: October 18, 2026

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